Jitofolate MCPY Tablet (10 Tab)

Medicine Information

Jitofolate MCPY Tablet Overview:

Jitofolate MCPY Tablet is a combination nutritional supplement used to manage neuropathic pain associated with diabetic neuropathy and to support treatment of endothelial dysfunction.

These underlying conditions can damage nerve cells, leading to a loss of peripheral sensitivity—most commonly causing altered sensations of warmth, cold, or numbness in the hands and feet.

To address this, Jitofolate MCPY Tablet is formulated with active, bioavailable forms of essential B-vitamins—Calcium L-5-Methyltetrahydrofolate, Methylcobalamin (Vitamin B12), and Pyridoxal-5-Phosphate (Vitamin B6). Working synergistically at the cellular level, these active nutrients facilitate nerve repair, support the healthy production of red blood cells, and regulate elevated homocysteine levels, which is essential for maintaining optimal vascular and neurological health.

 

Composition:

Each film coated tablet contains- Calcium L-5-Methyltetrahydrofolate: 1 mg, Methylcobalamin: 1500 mcg, Pyridoxal-5-Phosphate: 0.5 mg and Excipients q.s.

Colours: Red Oxide of Iron & Titanium Dioxide

Appropriate overages of vitamin added to compensate for loss on storage.

 

Uses & Benefits of Jitofolate MCPY Tablet:

Jitofolate MCPY Tablet is primarily used to manage and support conditions related to nutritional deficiencies and nerve damage, including:

• Diabetic & Peripheral Neuropathy: Helps repair and regenerate damaged peripheral nerves and relieve neuropathic symptoms such as numbness, tingling, sharp pain, and burning sensations—particularly in the hands and feet.
• Hyperhomocysteinemia & Endothelial Dysfunction: Helps lower abnormally high blood levels of homocysteine. By regulating homocysteine metabolism, it protects blood vessels, improves endothelial function, and reduces related cardiovascular and microvascular risks.
• Megaloblastic Anemia & B-Vitamin Deficiencies: Facilitates proper red blood cell synthesis and DNA repair, effectively managing folate and Vitamin B12 deficiency states to combat persistent fatigue, weakness, and anemia.
• Pregnancy & Prenatal Care: Delivers the active form of folate, Calcium L-5-Methyltetrahydrofolate, to support healthy neural tube formation, promote normal fetal development, and help lower the risk of certain birth defects when used under medical supervision.

How Does Jitofolate MCPY Tablet Work:

Jitofolate MCPY Tablet combines three bioavailable, active forms of B-vitamins such as Calcium L-5-Methyltetrahydrofolate Calcium, Methylcobalamin, and Pyridoxal-5-Phosphate that work synergistically at the cellular level to manage nutritional deficiencies, support vascular function, and promote nerve health.

Calcium L-5-Methyltetrahydrofolate Calcium (Active Vitamin B9) is the biologically active form of folate that enters the systemic circulation directly without requiring enzymatic conversion (such as by the MTHFR enzyme). It plays a pivotal role in DNA synthesis, cellular repair, and effectively lowering toxic homocysteine levels.

Furthermore, Methylcobalamin (Active Vitamin B12) acts as an active coenzyme that promotes myelin sheath synthesis—the essential protective coating surrounding nerve fibers. Regenerating damaged peripheral nerves, it helps restore healthy nerve conduction while simultaneously supporting normal red blood cell production.

Additionally, Pyridoxal-5-Phosphate (Active Vitamin B6) functions as the primary active coenzyme of Vitamin B6. It works together with Calcium L-5-Methyltetrahydrofolate and Methylcobalamin to optimize amino acid metabolism, facilitate neurotransmitter synthesis, and maintain healthy homocysteine balance.

 

Dosage of Jitofolate MCPY Tablet:

• Usage Directions

Take Jitofolate MCPY Tablet strictly according to your doctor’s instructions, following the prescribed dose and timing. Jitofolate MCPY Tablet should be swallowed whole and not chewed, cut, or crushed, preferably at the same time each day. Do not stop or alter the dose of Jitofolate MCPY Tablet without consulting your doctor, as this may prevent you from achieving the desired outcome. If you are unsure about the administration procedures of Jitofolate MCPY, consult with your doctor or pharmacist.

• Missed Dose

If you miss a dose of Jitofolate MCPY Tablet, take it as soon as you remember on the same day. But if it is almost time for your next scheduled dose, skip the one you missed and continue following your regular dosing schedule. Do not take double doses if you have forgotten one.

If you often forget to take your medication, you can set reminders on your smartphone, keep drug organizer boxes, or use other audio-visual technologies to prevent missing a dose.

• Overdose

Taking more than the recommended dose of Jitofolate MCPY Tablet may cause mild gastrointestinal discomfort or sensory disturbances. In case of an accidental overdose, seek immediate medical attention or contact a poison control center right away. Management typically involves symptomatic and supportive clinical care.

 

Contraindications of Jitofolate MCPY Tablet:

Do not take Jitofolate MCPY Tablet if you have a known hypersensitivity or allergy to Calcium L-5-Methyltetrahydrofolate, Methylcobalamin, Pyridoxal-5-Phosphate, or any of the inactive components of this medication.

 

Precautions & Warnings of Jitofolate MCPY Tablet:

Before starting Jitofolate MCPY Tablet, it is essential to inform your healthcare provider of your complete medical history. Consult a doctor if you have underlying kidney or liver diseases, as dose adjustments or monitoring may be needed.

Additionally, proper diagnostic evaluation is recommended before treatment, as high doses of folate can correct anemia and obscure the hematological indicators of an underlying Vitamin B12 deficiency. If B12 status is not properly monitored, irreversible neurological damage can continue to progress.

 

Side Effects of Jitofolate MCPY Tablet:

Jitofolate MCPY Tablet is generally well-tolerated by most individuals. However, some patients may experience mild, transient side effects, including gastrointestinal discomfort such as nausea, abdominal bloating, flatulence, loss of appetite, or mild diarrhea, as well as central nervous system effects like headaches or mild dizziness. Although rare, certain severe side effects require immediate medical intervention. These include hypersensitivity reactions (such as skin rash, severe itching, or whole-body edema), acne, elevated liver enzymes, and polycythemia vera. If you experience any persistent or severe adverse reactions, discontinue use and consult your physician promptly.

 

Safety Related Concerns of Jitofolate MCPY Tablet:

• Pregnancy

Jitofolate MCPY Tablet should be used with caution and must be taken strictly as prescribed by a gynecologist. If you are pregnant, suspect you may be pregnant, or are planning a pregnancy, consult your physician prior to initiating therapy to ensure the clinical benefits are carefully weighed against any potential risks to fetal development.

• Breastfeeding

It is not fully established to what extent the active ingredients in Jitofolate MCPY Tablet pass into human breast milk or whether they pose any risk to a nursing infant. Therefore, lactating mothers should always consult their physician before using this medication to assess the safety and clinical necessity during breastfeeding.

• Alcohol

Avoid or limit alcohol consumption while taking Jitofolate MCPY Tablet. Chronic alcohol intake impairs the intestinal absorption and utilization of folate and Vitamin B12.

• Food Interactions

Jitofolate MCPY Tablet may be taken with or without food, or strictly as directed by your physician to ensure optimal absorption. While there are no significant direct food-drug interactions reported, taking the tablet after meals may help minimize potential mild gastric discomfort.

Additionally, consuming a balanced diet rich in leafy green vegetables, whole grains, and nutrient-dense foods naturally complements therapy and supports overall nutrient metabolism.

• Drug Interactions

Jitofolate MCPY Tablet can interact with various medications, either by changing their effectiveness or increasing the risk of toxicity. Concomitant use with antiepileptic drugs (such as phenytoin, carbamazepine, or phenobarbital) or chemotherapeutic agents (like methotrexate) can compromise medication effectiveness due to folate antagonism.

Additionally, long-term use of acid reflux medications—including Proton Pump Inhibitors (e.g., omeprazole) and H2-receptor antagonists—as well as biguanide antidiabetics (such as metformin), can reduce the intestinal absorption of Vitamin B12 over time.

Always inform your healthcare provider of all prescription medications, over-the-counter drugs, and herbal supplements you are taking before starting treatment.

• Using Machinery & Driving

Jitofolate MCPY Tablet does not typically affect alertness, reaction time, or motor coordination. However, if you experience side effects such as dizziness or drowsiness, exercise caution and refrain from driving, operating heavy machinery, or performing tasks that require full mental focus until you feel completely attentive.

 

Storage of Jitofolate MCPY Tablet:

Store in a cool, dry & dark place. Protect from direct sunlight. Keep the medicine out of reach of children.

Do not use it once the expiration date on the packaging has been reached. Properly dispose of any expired or unused medications; do not throw it away casually.

 

Additional Information:

• Complement supplement therapy by consuming folate-rich foods (leafy green vegetables, legumes, citrus fruits) and B12-rich foods (dairy, eggs, fish, and fortified foods).
• For diabetic neuropathy management, strictly monitor blood glucose levels, maintain regular low-impact exercise (such as yoga or light walking), and avoid smoking.
• Avoid taking heavy caffeinated beverages (tea/coffee) immediately alongside your supplement to ensure optimal gastrointestinal absorption.
• Do not stop taking your medication suddenly unless your doctor specifically instructs you.
• Do not share your medicine with someone else who has the same symptoms.

 

Frequently Asked Questions (FAQs):

 

Q: What are the benefits of Jitofolate MCPY Tablet?

A: Jitofolate MCPY Tablet is primarily beneficial for treating or preventing B-vitamin deficiencies, managing endothelial dysfunction to support vascular health, and alleviating neuropathic pain associated with diabetic neuropathy. By providing bioavailable forms of essential B-vitamins, it promotes nerve repair, aids in red blood cell production, and helps maintain healthy homocysteine levels.

 

Q: What makes Jitofolate MCPY Tablet different from regular folic acid tablets?

A: Jitofolate MCPY Tablet contains Calcium L-5-Methyltetrahydrofolate, the active form of folate that the body can use directly. Unlike regular folic acid, it does not need to be converted before it starts working. It also contains Vitamin B12 (Methylcobalamin) and Vitamin B6 (Pyridoxal-5-Phosphate), which help support nerve health, red blood cell formation, and overall well-being. It should be taken as advised by your doctor.

 

Q: How long should I take Jitofolate MCPY Tablet?

A: The duration of treatment depends on the underlying medical condition being treated, as well as the severity of your nutritional deficiency or neurological symptoms. It should be taken strictly for the entire duration prescribed by your doctor. Do not alter the dose or stop taking the medication abruptly without consulting your healthcare provider, as doing so may delay recovery or affect treatment efficacy.

 

Q: Can diabetic patients safely take Jitofolate MCPY Tablet?

A: Yes, diabetic patients can safely take Jitofolate MCPY Tablet under medical supervision. In fact, it is frequently prescribed for individuals with diabetes to manage or prevent diabetic peripheral neuropathy and to promote nerve repair. Additionally, long-term use of certain anti-diabetic medications, such as metformin, can impair Vitamin B12 absorption over time.

 

Q: Can Jitofolate MCPY Tablet be taken alongside other multivitamin supplements?

A: You should consult your healthcare provider before combining Jitofolate MCPY Tablet with other dietary supplements. Taking multiple products containing folic acid, Vitamin B12, or Vitamin B6 may lead to exceeding the recommended daily intake levels unnecessarily.

 

Q: Is Jitofolate MCPY Tablet safe for long-term use?

A: Jitofolate MCPY Tablet is generally safe for extended use when taken under medical supervision. Your doctor may periodically evaluate your B-vitamin levels, kidney function, and overall health status to determine the appropriate duration of therapy.

 

Q: Are there any specific dietary restrictions while taking Jitofolate MCPY Tablet?

A; There are no strict food restrictions; however, it is advisable to limit excessive alcohol consumption, as chronic alcohol intake impairs the intestinal absorption and utilization of essential B-vitamins like folate and B12. Additionally, maintaining a well-balanced diet rich in leafy greens and whole foods supports overall nutrient efficacy.

 

 

 

References:

1. Nuring Active. Calcium L-5-Methyltetrahydrofolate + Mecobalamin + Pyridoxal 5’-phosphate. Last Revised: January 2022. Accessed on: 5th August 2026. Click Here

2. FOLIGRACE SG. Accessed on: 5th August 2026. Click Here