Jitotel CLCH 40/10/12.5 Tablet (10 Tab)

Medicine Information

Jitotel CLCH 40/10/12.5 Tablet Overview:

Jitotel CLCH 40/10/12.5 Tablet is a combination antihypertensive medication used for the effective management of essential hypertension (high blood pressure), particularly when single or dual-drug therapies are insufficient.

High blood pressure is a common, long-term condition that puts extra strain on the heart and blood vessels. If left uncontrolled, it can gradually damage blood vessels and increase the risk of serious complications, including stroke, heart attack, and heart or kidney disease.

To provide comprehensive blood pressure regulation, Jitotel CLCH 40/10/12.5 Tablet combines three complementary agents: Cilnidipine, a dual L- and N-type calcium channel blocker that relaxes vascular smooth muscle and promotes vasodilation. Telmisartan, an angiotensin II receptor blocker that prevents blood vessel constriction to improve blood flow; and Chlorthalidone, a long-acting thiazide-like diuretic that helps the body eliminate excess fluid and sodium.

Together, these active ingredients exert a synergistic effect—combining targeted vasodilation with fluid reduction—to achieve optimal blood pressure control and safeguard long-term cardiovascular health.

 

Composition:

Each film coated tablet contains- Telmisartan: 40 mg, Chlorthalidone: 12.5 mg, Cilnidipine: 10 mg, and Excipients q.s.

Colours: Red Oxide of Iron & Titanium Dioxide

 

Uses & Benefits of Jitotel CLCH 40/10/12.5 Tablet:

The therapeutic uses and benefits of Jitotel CLCH 40/10/12.5 Tablet include:

• Essential Hypertension: Indicated for the management of high blood pressure in adult patients whose blood pressure is not adequately controlled with monotherapy or dual combination therapy.
• Cardiovascular Risk Reduction: Promotes consistent arterial relaxation to lower systemic blood pressure, substantially reducing the long-term risk of major adverse cardiovascular events such as myocardial infarction (heart attack), heart failure, and stroke.
• Renal Protection: Asserts kidney-protective effects by reducing filtration pressure and managing fluid overload associated with chronic hypertension.

 

How Does Jitotel CLCH 40/10/12.5 Tablet Work:

Jitotel CLCH 40/10/12.5 Tablet combines three active ingredients—Cilnidipine, Telmisartan, and Chlorthalidone—that work through complementary pathways to lower systemic blood pressure.

Cilnidipine is a dual L- and N-type calcium channel blocker that inhibits calcium influx in both vascular smooth muscle and sympathetic nerve endings. This dual action promotes arterial vasodilation to lower blood pressure while effectively preventing reflex tachycardia.

Telmisartan is a selective angiotensin II receptor blocker. Selectively blocks the binding of Angiotensin II to AT1 receptors, preventing blood vessel constriction and suppressing aldosterone secretion. As a result, it reduces vascular resistance and improves blood flow.

Additionally, Chlorthalidone is a thiazide diuretic, also known as a "water pill." It acts on the renal tubules to inhibit sodium and chloride reabsorption, promoting the elimination of excess water and sodium from the body to reduce overall circulating blood volume.

 

Dosage of Jitotel CLCH 40/10/12.5 Tablet:

• Usage Directions

Take Jitotel CLCH 40/10/12.5 Tablet strictly according to your doctor’s instructions, following the prescribed dose and timing. Jitotel CLCH 40/10/12.5 Tablet should be swallowed whole with water and not chewed, cut, or crushed, preferably at the same time each day. Do not stop or alter the dose of Jitotel CLCH 40/10/12.5 Tablet without consulting your doctor, as this may prevent you from achieving the desired outcome. If you aren't sure how to take Jitotel CLCH 40/10/12.5, check with your healthcare provider or pharmacist for instructions.

• Missed Dose

If you miss a dose of Jitotel CLCH 40/10/12.5 Tablet, take it as soon as you remember on the same day. If it's almost time for your next application, skip the missed dose and proceed with your usual routine. Do not take double doses in case if you have forgotten one. To avoid missing doses, set reminders on your smartphone, keep drug organizer boxes, or use other audio-visual technologies.

• Overdose

If you accidentally take Jitotel CLCH 40/10/12.5 Tablet more than your prescribed dose, seek immediate medical advice or contact a poison control center immediately. Overdose may cause severe hypotension (excessively low blood pressure), extreme dizziness, electrolyte disturbances, and bradycardia or tachycardia.

 

Contraindications of Jitotel CLCH 40/10/12.5 Tablet:

Do not take Jitotel CLCH 40/10/12.5 Tablet if you have a known allergy or hypersensitivity to Cilnidipine, Telmisartan, Chlorthalidone, sulfonamide-derived drugs, or any other inactive component present in this medication.

The medication is contraindicated in patients with severe cardiovascular compromise (such as cardiogenic shock, recent myocardial infarction, acute unstable angina, or severe aortic stenosis), severe renal impairment, anuria, biliary obstructive disorders, or untreated Addison’s disease.

Furthermore, its use is prohibited in patients with refractory electrolyte imbalances (including hypokalemia, hyponatremia, and hypercalcemia) and symptomatic hyperuricemia (gout), as well as in combination with lithium therapy or aliskiren in individuals with diabetes mellitus or renal disease.

 

Precautions & Warnings of Jitotel CLCH 40/10/12.5 Tablet:

Before starting Jitotel CLCH 40/10/12.5 Tablet, inform your healthcare provider about your complete medical history. Caution and dosage adjustments may be required for elderly individuals and those with mild-to-moderate hepatic impairment.

Routine periodic monitoring of renal function and serum electrolytes—including sodium, potassium, chloride, and calcium—is essential for detecting and preventing biochemical imbalances during therapy.

Patients should be closely monitored for symptomatic hypotension (excessively low blood pressure), particularly those who are volume- or salt-depleted due to dietary restrictions, persistent vomiting, diarrhea, or concurrent diuretic use.

Additionally, close monitoring of serum uric acid levels is advised, as the thiazide-like diuretic component may induce hyperuricemia or precipitate acute gout flares in susceptible individuals.

 

Side Effects of Jitotel CLCH 40/10/12.5 Tablet:

Like all medicines, Jitotel CLCH 40/10/12.5 Tablet can cause side effects, although not everyone will experience them. Most commonly reported symptoms are mild to moderate, which include dizziness, lightheadedness, headache, peripheral edema (ankle swelling), fatigue, orthostatic hypotension, gastrointestinal disturbances (nausea, vomiting, diarrhea, loss of appetite), and dermatological reactions such as urticaria or skin rashes.

Less common but significant adverse reactions include electrolyte and metabolic disturbances (hypokalemia, hyponatremia, hypomagnesemia, hypercalcemia, hyperglycemia, hyperuricemia, and acute gout), cardiac arrhythmias, paresthesia, jaundice, elevated serum blood urea and creatinine, and, rarely, pancreatitis or non-cardiogenic pulmonary edema.

Patients experiencing severe, persistent symptoms or signs of a serious reaction—such as chest pain, irregular heartbeat, or angioedema—should seek prompt medical attention.

 

Safety Related Concerns of Jitotel CLCH 40/10/12.5 Tablet:

• Pregnancy

Jitotel CLCH 40/10/12.5 Tablet must be avoided during pregnancy due to the potential risk of fetal damage from its active ingredients. If pregnancy is diagnosed or planned, the medication must be discontinued immediately under medical guidance to transition to a safer alternative for managing your blood pressure.

Label Warning: When pregnancy is detected, discontinue Telmisartan as soon as possible. Drugs that ac directly on the renin-angiotensin system can cause injury and death to the developing fetus.

• Breastfeeding

The use of Jitotel CLCH 40/10/12.5 Tablet is not recommended during lactation. It is not fully established whether its active ingredients pass into human breast milk and may possess potential risks of adverse effects on the nursing infant. Therefore, consulting with your doctor before taking Jitotel CLCH 40/10/12.5 is crucial.

• Alcohol

Avoid consuming alcohol while taking this medication. Alcohol can enhance the blood-pressure-lowering effect of Jitotel CLCH 40/10/12.5, significantly increasing the risk of orthostatic hypotension, a sudden drop in blood pressure that occurs when standing up, which may lead to dizziness or fainting.

• Food Interactions

Jitotel CLCH 40/10/12.5 Tablet is usually suggested to be taken with or without food, as there are no known food-drug interactions. However, patients should follow a low-sodium diet and avoid high-salt items such as processed snacks, cured meats, and pickles, as excess sodium directly counteracts the blood pressure-lowering effectiveness of the medication.

Additionally, avoid potassium supplements and potassium-rich salt substitutes unless specifically prescribed by a healthcare provider.

• Drug Interactions

Jitotel CLCH 40/10/12.5 Tablet may interact with other medicines, either by compromising their effectiveness or increasing the risk of toxicity. If you are taking lithium, other blood pressure medications (especially Aliskiren), ACE inhibitors, NSAIDs, digitalis glycosides (digoxin), and potassium supplements.

Furthermore, potential interactions occur with CNS depressants (barbiturates, narcotics, sedatives), which may exacerbate orthostatic hypotension, as well as with corticosteroids, antidiabetic agents (insulin and oral hypoglycemics), and lipid-lowering resins such as cholestyramine.

Always provide your doctor with a complete list of all prescription medications, over-the-counter products, and supplements before starting treatment.

• Using Machinery & Driving

Jitotel CLCH 40/10/12.5 Tablet may cause transient dizziness or fatigue, especially during initial therapy. Patients should use caution and avoid driving or operating machinery until they are sure the medication does not affect their alertness.

 

Storage of Jitotel CLCH 40/10/12.5 Tablet:

Store protected from light and moisture at a temperature below 30°C. Keep the medicine out of reach of children.

Discard and do not take this medication after the expiration date printed on the package. It is important to dispose of expired or unused medications properly; do not throw them away casually.

 

 

Helpful Tips:

• Adopt a Dietary Approaches to Stop Hypertension (DASH) eating plan rich in whole grains, fruits, vegetables, and low-fat dairy products.
• Limit dietary salt intake to enhance the medication's therapeutic efficacy.
• Engage in mild to moderate aerobic exercise weekly and maintain a healthy body mass index (BMI).
• Routinely monitor your blood pressure at home and maintain a detailed log to share with your physician during follow-up visits.
• Check your kidney function, liver function, and electrolyte levels (potassium, sodium, and magnesium) are essential, especially if you have pre-existing conditions.
• Do not discontinue treatment without consulting your physician.
• Never share your medicine with others, even if they have similar symptoms, because this is a prescription drug tailored specifically for you.

 

 

Frequently Asked Questions (FAQs):

Q: Why is Jitotel CLCH 40/10/12.5 Tablet prescribed?

A: Jitotel CLCH 40/10/12.5 Tablet is prescribed for the management of high blood pressure (essential hypertension) in adults whose blood pressure is not adequately controlled with a single medication or dual-drug therapy.

 

Q: Can I stop taking Jitotel CLCH 40/10/12.5 Tablet once my blood pressure normalizes?

A: No. Normal blood pressure readings indicate that the medication is actively working, not that the underlying condition is cured. Hypertension is a chronic condition that requires continuous management, and stopping the medicine abruptly can lead to a dangerous rebound spike in blood pressure. Always speak with your physician before modifying your dosage.

 

Q: Can Jitotel CLCH 40/10/12.5 Tablet affect blood sugar or uric acid levels?

A: Yes. The Chlorthalidone component can occasionally elevate blood glucose levels and serum uric acid (which may trigger gout in susceptible patients). If you have diabetes or a history of gout, your doctor will monitor these levels closely.

 

Q: Does Jitotel CLCH 40/10/12.5 Tablet cause dizziness when standing up?

A: Yes, it can cause postural dizziness (orthostatic hypotension), especially during the initial weeks of treatment or after a dose increase. This occurs when blood pressure drops temporarily upon standing. To prevent lightheadedness or falls, rise slowly and steadily from a sitting or lying position.

 

Q: Will I need to have regular blood tests while on this medicine?

A: Yes. Your doctor will periodically check your kidney function (creatinine, BUN) and serum electrolytes (potassium, sodium, calcium, uric acid) to ensure the medication is working safely and has not caused chemical imbalances.

 

Q: What should I do if my blood pressure drops too low (hypotension)?

A: If you experience symptoms of low blood pressure—such as severe dizziness, clammy skin, confusion, or fainting—lie down immediately with your legs elevated to improve blood flow to the brain, drink a glass of water, and contact your doctor for dosage guidance.

 

Q: Can Jitotel CLCH 40/10/12.5 affect sexual function?

A: Thiazide diuretics like Chlorthalidone can occasionally contribute to mild erectile dysfunction or decreased libido in some men. If you notice persistent sexual side effects, discuss it with your physician rather than stopping the medication on your own, as alternative options are available.

 

 

 

References:

1. CILACAR® TC 6.25. Cilnidipine, Telmisartan & Chlorthalidone Tablets. Last Revised: November 2021. Accessed on: 18th August 2026. Click Here

2. TORCILIN TRIO. Cilnidipine 10 mg, Telmisartan 40 mg & Chlorthalidone 6.25 mg Tablets. Last Revised: August 2025. Accessed on: 18th August 2026. Click Here