Jitopreg MC 75/750 Capsule (10 Cap)

Medicine Information

Jitopreg MC 75/750 Capsule Overview:

Jitopreg MC 75/750 Capsule is a combination medication primarily used to manage various forms of neuropathic pain due to chronic nerve damage.

Jitopreg MC 75/750 Capsule is effective in addressing diabetic neuropathy, peripheral neuropathy, and neuropathic pain from spinal cord injuries, fibromyalgia, chronic pain syndromes, and pain management during surgical procedures.

It contains Pregabalin and Methylcobalamin (Vitamin B12), which work together to relieve nerve pain and support nerve repair. Pregabalin calms overactive nerve signals by reducing calcium entry into nerve cells, helping to relieve pain. Methylcobalamin helps form the protective covering (myelin) around nerves and supports the repair and regeneration of damaged nerve tissue. Together, they help reduce nerve pain while promoting healthy nerve function and recovery.

 

Composition:

Each hard gelatin capsule contains- Pregabalin: 75 mg, Methylcobalamin: 750 mcg, and Excipients q.s.

Approved colours used in empty capsule shell.

Appropriate overages of vitamins added to compensate any loss on storage.

 

Uses & Benefits of Jitopreg MC 75/750 Capsule:

Jitopreg MC 75/750 Capsule is prescribed to manage conditions caused by progressive nerve damage, which include:

• Neuropathic Pain: It acts as a specialized treatment for chronic pain conditions that stem directly from progressive, underlying nerve damage or a malfunctioning nervous system.
• Diabetic Neuropathy: It effectively alleviates the burning, tingling, or stabbing nerve pain commonly experienced in the hands and feet due to long-term elevated blood sugar levels.
• Postherpetic Neuralgia: It helps soothe the debilitating, persistent nerve pain that lingers after a shingles (herpes zoster) rash infection has completely healed.
• Spinal Cord Injury or Sciatica: It reduces severe radiating pain caused by physical compression, inflammation, or trauma to the spinal cord and spinal nerve roots.
• Fibromyalgia: It addresses widespread musculoskeletal pain, fatigue, and heightened tenderness by calming the altered, hyper-responsive sensory processing within the central nervous system.

 

How Does Jitopreg MC 75/750 Capsule Work:

The two active components of Jitopreg MC 75/750 Capsule, Pregabalin and Methylcobalamin, work synergistically to alleviate nerve pain and promote structural healing.

Pregabalin is an antiepileptic agent that functions as a neuropathic pain modulator. It binds to calcium channels present in the nerve cells of the central nervous system, reducing the release of specific pain-signaling neurotransmitters, including glutamate and substance P. Thus, it reduces the transmission of excessive pain signals.

Concurrently, Methylcobalamin, an active coenzyme form of Vitamin B12, addresses the underlying structural damage by playing a critical role in the synthesis of myelin sheath. It is the protective lipid sheath that coats, insulates, and preserves nerve fibers. Promoting myelin production—it helps facilitate the repair, regeneration, and functional recovery of damaged peripheral nerves.

 

Dosage of Jitopreg MC 75/750 Capsule:

• Usage Direction

Take Jitopreg MC 75/750 Capsule exactly as advised by your doctor’s, following the prescribed dose and timing. Jitopreg MC 75/750 Capsule should be swallowed whole with water without breaking, chewing, or crushing it, preferably at the same time each day. Do not stop or alter the dose of Jitopreg MC 75/750 Capsule without consulting your doctor, as this may prevent you from achieving the desired outcome. If you are unsure about the administration procedures of Jitopreg MC 75/750, consult with your doctor or pharmacist.

• Missed Dose

If you miss a dose of Jitopreg MC 75/750 Capsule, take it as soon as you remember on the same day. But, if it is almost time for your next scheduled dose, skip the one you missed and continue following your regular dosing schedule. Do not take double doses if you have forgotten one.

If you often forget to take your medication, you can set reminders on your smartphone, keep drug organizer boxes, or use other audio-visual technologies to prevent missing a dose.

• Overdose

If you accidentally take Jitopreg MC 75/750 Capsule more than your prescribed dose, seek immediate medical advice, as this may lead to serious side effects. An overdose may cause sleepiness, confusion, agitation, restlessness, and seizures. Management of overdose could be done through supportive care, which may include haemodialysis if necessary.

 

Contraindications of Jitopreg MC 75/750 Capsule:

Do not take Jitopreg MC 75/750 Capsule if you have a known allergy or hypersensitivity to Pregabalin, Methylcobalamin, or any other ingredients present in this medicine.

Patient should not take it with a history of angioedema (severe swelling of the face, tongue, or throat) related to prior pregabalin use.

 

Precautions & Warnings of Jitopreg MC 75/750 Capsule:

Before starting Jitopreg MC 75/750 Capsule, discuss your complete medical history with your healthcare provider. Because pregabalin is eliminated unchanged through the kidneys, patients with renal impairment require precise dosage adjustments to prevent drug accumulation and toxicity.

As an antiepileptic medication, it carries a small risk of inducing suicidal thoughts or behaviors; closely monitor for any sudden changes in mood or anxiety.

To avoid withdrawal symptoms like severe insomnia, nausea, headache, or increased nerve pain, it must never be discontinued abruptly, and the dose should always be tapered gradually under medical supervision.

Furthermore, Jitopreg MC 75/750 can cause unexplained weight gain and peripheral edema (fluid retention in the hands, ankles, or feet). It must be used with caution if you have a history of congestive heart failure.

Finally, it is suggested to have periodic vision check-ups due of the risks associated with blurred vision, and clinical monitoring is recommended for those with pre-existing heart conditions, as the medication can prolong the PR interval and may sometimes lower platelet counts.

 

Side Effects of Jitopreg MC 75/750 Capsule:

While taking Jitopreg MC 75/750 Capsule, you may experience side effects; however, most of them are mild and temporary as your body adjusts to the medication. Common side effects may include headache, dizziness, sleepiness, dry mouth, blurred vision, constipation, weight gain, difficulty concentrating, or memory impairment.

Conversely, rare serious side effects may also occur, requiring immediate medical advice. These symptoms include suicidal thoughts, peripheral edema, and allergic reaction characterized by swelling of your face, mouth, lips, gums, tongue, and neck.

 

Safety Related Concerns of Jitopreg MC 75/750 Capsule:

• Pregnancy

Jitopreg MC 75/750 Capsule should be used with caution during pregnancy, as limited data exist regarding the safety in pregnant women. If you are pregnant or planning to become pregnant, talk to your doctor before taking this medication to weigh the benefits against potential risks to the developing baby.

• Breastfeeding

It is better to avoid Jitopreg MC 75/750 Capsule while breastfeeding, since one of its active ingredients could pass into the breast milk and affect the breastfed child. Therefore, consulting with your doctor before taking Jitopreg MC 75/750 Capsule is crucial.

• Alcohol

Avoid alcohol consumption while taking Jitopreg MC 75/750 Capsule. Alcohol can profoundly worsen central nervous system depression, leading to severe dizziness, drowsiness, impaired coordination, and respiratory depression.

• Food Interactions

There are no significant food interactions associated with Jitopreg MC 75/750 Capsule. It can be taken with or without meals as suggested.

To ensure safety, patients with known food allergies or dietary restrictions should consult their healthcare professional before starting the medication.

• Drug Interactions

Jitopreg MC 75/750 Capsule can interact with a wide variety of medications, which can either compromise their effectiveness or increase the risk of toxicity. It is suggested to avoid taking this medication concurrently with central nervous system (CNS) depressants—such as opioids (oxycodone), benzodiazepines (lorazepam), or ethanol (alcohol), as it can dangerously potentiate sedative effects, cause profound dizziness, and induce respiratory depression. Additionally, caution is advised when combining pregabalin with antidiabetic agents, such as thiazolidinediones (e.g., pioglitazone), which can cause fluid retention and peripheral edema.

Always inform your healthcare provider and pharmacist about all medications you are taking, including prescription drugs, over-the-counter medications, vitamins, minerals, and herbal supplements, to avoid potential interactions.

• Using Machinery & Driving

Do not perform activities that require full attention, such as driving or operating machinery, until you know how this medicine affects you. Dizziness and drowsiness are very common side effects of Jitopreg MC 75/750 Capsule, which can significantly impair your reaction times and motor skills.

 

Storage of Jitopreg MC 75/750 Capsule:

Store protected from light & moisture at a temperature not exceeding 30°C. Keep medicine out of reach of children.

Avoid using it once the expiry date on the packaging has been reached. Properly dispose of any expired or unused medications; do not throw it away casually.

 

Additional Information:

• Ensure adequate intake of dietary sources rich in B-complex vitamins, antioxidants, and essential fatty acids. Foods like leafy greens, lean proteins, nuts, and seeds support general nerve function and combat oxidative stress.
• If the nerve damage is secondary to diabetes, maintaining strict blood glucose control through tailored carbohydrate awareness and regular monitoring is fundamental to preventing the progression of neuropathy.
• Regular, low-impact exercises such as swimming, walking, or stationary cycling enhance blood circulation to peripheral nerves, which can alleviate pain severity over time.
• For individuals spending extensive periods at a desk or in sedentary environments, implementing proper lumbar support, keeping feet flat on the floor, and scheduling brief movement breaks every hour can reduce mechanical stress on the spine and peripheral nerve pathways.
• Individuals with peripheral neuropathy should perform daily foot inspections to detect minor cuts, blisters, or calluses early, mitigating the risk of unnoticed infections due to reduced sensation.
• Do not share your medicine with someone else having the same symptoms as you, as the drug requires a prescription.

 

 

Frequently Asked Questions (FAQs):

Q. Why Jitopreg MC 75/750 Capsule is prescribed?

A. Jitopreg MC 75/750 Capsule is prescribed to manage neuropathic pain, which is chronic pain caused by damage or injury to the nervous system. It is commonly used to treat nerve pain associated with diabetic neuropathy, shingles (postherpetic neuralgia), sciatica, spinal cord injuries, and widespread conditions like fibromyalgia. It works by both calming overactive nerve signals and supporting the physical repair of damaged nerve fibers.

 

Q. Can I stop taking Jitopreg MC 75/750 when my pain subsides?

A. No, you should not discontinue this medication without consulting your physician. Stopping it abruptly can trigger withdrawal symptoms or cause your nerve pain to return aggressively. Your doctor will provide a schedule to taper off the medication safely.

 

Q. Does Jitopreg MC 75/750 Capsule cure nerve damage completely?

A. No, it does not cure all types of nerve damage. While Methylcobalamin supports nerve health and aids in repairing the protective myelin sheath, and Pregabalin manages the painful symptoms, whether the damage can be fully reversed depends heavily on the underlying cause. The primary goal of Jitopreg MC 75/750 Capsule is to significantly reduce pain, protect remaining nerve fibers, and improve the patient's overall quality of life.

 

Q. Why am I experiencing severe drowsiness and dizziness after taking Jitopreg MC 75/750 Capsule?

A. Drowsiness and dizziness are the common side effects of Jitopreg MC 75/750 Capsule, as it actively works by calming hyperactive nerve signals in the brain and central nervous system. These sensations are usually observed during the first few days of starting the medication or after a dose increase. Because of this, it is recommended to avoid driving, operating heavy machinery, or consuming alcohol while taking it.

 

Q. Can I take pain relievers (like paracetamol or ibuprofen) with Jitopreg MC 75/750 Capsule?

A. Yes, Jitopreg MC 75/750 Capsule can generally be taken with pain relievers such as paracetamol or ibuprofen if recommended by your doctor. There are no major interactions between these medicines, and they may sometimes be prescribed together to provide better pain relief, depending on the underlying condition. However, avoid self-medicating for prolonged periods, and consult your doctor before combining medications, especially if you have kidney disease, stomach ulcers, liver problems, or are taking other prescription medicines. Use all medicines exactly as directed by your healthcare provider.

 

 

 

References:

1. PREGABALIN (75 MG) & METHYLCOBALAMIN (750 MCG) CAPSULES. Administrative information and prescribing information. Last Revised: May, 2018. Accessed on: 3rd August 2026. Click Here

2. Nervagest Plus. 75 mg / 750 mcg Capsule. Last Revised: Feb 18th, 2020. Accessed on: 3rd August 2026. Click Here

3. SAGALIN- M 750 & SAGALIN- M 1500. Pregabalin & Methylcobalamin Capsules. Accessed on: 3rd August 2026. Click Here