Jitogaba NT 400/10 Tablet (10 Tab)

Medicine Information

Jitogaba NT 400/10 Tablet Overview:

Jitogaba NT 400/10 Tablet is a used to manage chronic (long-lasting) neuropathic pain (nerve pain), including refractory neuropathic pain and post-herpetic neuralgia.

This long-term nerve pain is typically caused by nerve damage resulting from conditions such as diabetes, shingles, or spinal cord injuries.

The medication combines two active salts, Gabapentin, an anticonvulsant that stabilizes hyperexcitable nerve cells, and Nortriptyline, a tricyclic antidepressant that alters pain-signaling pathways in the central nervous system. Together, they provide a synergistic effect, targeting nerve discomfort more effectively than either drug alone.

Jitogaba NT 400/10 Tablet also helps reduce its associated systemic symptoms, such as mood changes, sleep disturbances, and chronic tiredness.

 

Composition:

Each film coated tablet contains- Gabapentin: 400 mg, Nortriptyline Hydrochloride Equivalent to Nortriptyline: 10 mg, and Excipients q.s.

 

Colours: Titanium Dioxide

 

Uses & Benefits of Jitogaba NT 400/10 Tablet:

Jitogaba NT Tablet is used for the treatment of neuropathic pain, which can manifest as burning, stabbing, throbbing, or shooting sensations. Specific conditions it helps manage include:

• Diabetic Neuropathy: Chronic nerve damage and pain caused by prolonged exposure to high blood sugar levels.
• Post-herpetic Neuralgia: Persistent, severe nerve pain that remains along a nerve pathway after a shingles (Herpes zoster) infection has cleared.
• Trigeminal Neuralgia: Sudden, severe facial pain resulting from disruption or compression of the trigeminal nerve.
• Spinal Cord Injury Pain: Chronic central neuropathic pain arising directly from trauma or damage to the central nervous system.

 

How Does Jitogaba NT 400/10 Tablet Work:

The two active ingredients in Jitogaba NT 400/10 Tablet, Gabapentin and Nortriptyline, work through complementary mechanisms to soothe and stabilize an overactive nervous system.

The component Gabapentin binds to specific alpha-2-delta subunits of voltage-gated calcium channels within the central nervous system. By regulating these channels, it reduces the release of excitatory neurotransmitters—the chemicals that transmit pain signals—effectively turning down the "volume" of chronic nerve pain.

Whereas Nortriptyline inhibits the reabsorption (reuptake) of neurotransmitters, specifically serotonin and norepinephrine, in the brain and spinal cord. Maintaining active levels of these chemicals strengthens the body's natural descending pain-inhibiting pathways.

Combined, this dual-action approach targets nerve discomfort from two different physiological angles, providing more comprehensive relief than single-agent therapies.

 

Dosage of Jitogaba NT 400/10 Tablet:

• Usage Direction

Take Jitogaba NT 400/10 Tablet exactly as advised by your doctor’s, following the prescribed dose and timing. Jitogaba NT 400/10 Tablet should be swallowed whole with water without breaking, chewing, or crushing it, preferably at the same time each day. Do not stop or alter the dose of Jitogaba NT Tablet without consulting your doctor, as this may prevent you from achieving the desired outcome. If you are unsure about the administration procedures of Jitogaba NT, consult with your doctor or pharmacist.

• Missed Dose

If you miss a dose of Jitogaba NT 400/10 Tablet, take it as soon as you remember on the same day. But, if it is almost time for your next scheduled dose, skip the one you missed and continue following your regular dosing schedule. Avoid taking two doses if you realize you've missed one. If you often frequently forget your medication, consult your doctor to reassess your dosing plan. Missing doses regularly can lead to undesired outcomes.

You can set reminders on your smartphone, keep drug organizer boxes, or use other audio-visual technologies to prevent missing a dose.

• Overdose

If you accidentally take Jitogaba NT 400/10 Tablet more than your prescribed dose, seek immediate medical advice, as this may lead to serious side effects. Symptoms of overdose may include severe dizziness, extreme drowsiness, blurred vision, rapid heartbeat, confusion, or fainting.

Management of overdose could be done through haemodialysis in case of severe overdose and supportive care.

 

Contraindications of Jitogaba NT 400/10 Tablet:

Do not take Jitogaba NT 400/10 Tablet if you have a known allergy or hypersensitivity to Gabapentin, Nortriptyline, other tricyclic antidepressants, or any other ingredients present in this medicine. Signs of a severe allergic reaction may include skin rash, pruritus (itching), dyspnea (difficulty breathing), or angioedema (swelling of the face, lips, tongue, or throat).

It is strictly contraindicated in patients who have recently suffered a heart attack (acute myocardial infarction) or have severe heart rhythm disorders (cardiac arrhythmias).

Individuals with severe liver disease or those experiencing mania (an elevated, abnormally excited mood state) should avoid taking this medication.

It must not be administered concurrently with, or within 14 days of discontinuing, Monoamine Oxidase Inhibitors (MAOIs). Combining these medications can precipitate a life-threatening drug reaction, such as serotonin syndrome or severe hypertensive crisis.

Additionally, Jitogaba NT is not recommended for use in pediatric patients, as its safety and efficacy have not been established in this age group.

 

Precautions & Warnings of Jitogaba NT 400/10 Tablet:

Before starting Jitogaba NT 400/10 Tablet, it is essential to consult your healthcare provider and thoroughly discuss your complete medical history.

Both antiepileptic (Gabapentin) and antidepressant (Nortriptyline) medications can increase the risk of suicidal thoughts or behaviors. Carefully monitor for sudden changes in mood, behavior, or worsening depression and report these symptoms to a physician immediately.

The kidneys are responsible for clearing the medication; careful dosage adjustments are required for patients with pre-existing kidney problems or those undergoing hemodialysis.

If you experience unexplained muscle pain, tenderness, or muscle weakness, inform your physician promptly, as this may indicate a serious underlying drug-related effect.

Furthermore, the medication may, in rare cases, lead to acute pancreatitis. Consult a healthcare professional immediately if you experience warning signs such as persistent, severe abdominal pain that may radiate to your back, accompanied by nausea and vomiting.

Use with extreme caution in patients with central nervous system (CNS) disorders, respiratory disorders, and elderly patients aged 65 years and older, who may be more susceptible to adverse effects like profound sedation or falls.

 

Side Effects of Jitogaba NT 400/10 Tablet:

While taking Jitogaba NT 400/10 Tablet, you may experience side effects; however, most of them are mild and temporary as your body adjusts to the medication. Common side effects may include dizziness, unsteadiness (ataxia), sleepiness, or fatigue, constipation, blurred vision, weight gain, and peripheral edema (swelling of the hands, ankles, or feet).

Serious side effects may be rare, but they require immediate medical intervention if they occur. You should contact your doctor right away if you experience hypertension, a suicide attempt, seizure, palpitations, persistent abdominal pain, yellowing of eyes or skin, renal failure, or severe allergic reactions.

 

Safety Related Concerns of Jitogaba NT 400/10 Tablet:

• Pregnancy

Jitogaba NT 400/10 Tablet is not recommended during pregnancy, unless prescribed by your doctor, as limited data exist regarding the safety in pregnant women. If you are pregnant or planning to become pregnant, talk to your doctor before taking this medication to weigh the benefits against potential risks to the developing baby.

• Breastfeeding

It is best to avoid Jitogaba NT 400/10 Tablet while breastfeeding, as both components pass into breast milk. Alternative treatments are preferred, or breastfeeding should be discontinued while using this drug, depending on clinical necessity.

• Alcohol

Avoid alcohol consumption while taking Jitogaba NT 400/10 Tablet. Alcohol severely intensifies the central nervous system depressant effects of this drug, leading to suicidal attempts, extreme drowsiness, respiratory depression, and dizziness.

• Food Interactions

There are no significant food interactions associated with Jitogaba NT 400/10 Tablet. It can be taken with or without meals as suggested.

To ensure safety, patients with known food allergies or dietary restrictions should consult their healthcare professional before starting the medication.

• Drug Interactions

Jitogaba NT 400/10 Tablet can interact with various medications, either by compromising their effectiveness or increasing the risk of toxicity. Concurrently taking the medication with ethanol (alcohol) or central nervous system (CNS) depressants like opioids (e.g., oxycodone) and benzodiazepines (e.g., lorazepam) severely increases the risk of respiratory failure, coma, and death. Meanwhile, it requires careful monitoring and dosage adjustments when co-administered with carbamazepine, phenothiazines, propafenone, flecainide, or enzyme inhibitors like quinidine.

Furthermore, Jitogaba NT can reduce the efficacy of antihypertensives (e.g., guanethidine, clonidine), prolong barbiturate-induced sedation, and alter plasma levels when coadministered with cimetidine or fluoxetine.

Crucially, combining it with Monoamine Oxidase Inhibitors (MAOIs) or other serotonergic drugs poses a severe risk of life-threatening serotonin syndrome.

Always inform your healthcare provider and pharmacist about all medications you are taking, including prescription drugs, over-the-counter medications, vitamins, minerals, and herbal supplements, to avoid potential interactions

• Using Machinery & Driving

Taking Jitogaba NT 400/10 Tablet may lead to sleepiness, dizziness, blurred vision, and signs of CNS depression that can severely impair coordination and reflexes. Do not drive or operate heavy machinery while taking this medication until you know exactly how it affects you.

 

Storage of Jitogaba NT 400/10 Tablet:

Store protected from light & moisture, at a temperature not exceeding 25°C. Keep out of reach of children.

Avoid using it after the expiry date, printed on the packaging. Dispose of expired or unused medication properly; do not throw it away casually.

 

 

Additional Information:

• For diabetic neuropathy, keeping blood glucose tightly controlled prevents further nerve deterioration.
• Ensure adequate intake of Vitamin B12, B6, and Folate, which support nerve repair and myelination. Talk to your doctor about appropriate supplements.
• Low-impact exercises like swimming, walking, or stretching improve blood circulation to peripheral nerves and reduce chronic pain perception.
• Smoking constricts blood vessels, reducing nutrient delivery to already damaged nerves. Quitting helps optimize nerve healing.
• Do not suddenly stop your medication unless your doctor specifically tells you to.
• Do not share your medicine with someone else having the same symptoms as you.

 

 

Frequently Asked Questions (FAQs):

 

Q. Why is Jitogaba NT 400/10 Tablet prescribed?

A. Jitogaba NT 400/10 Tablet is prescribed to manage chronic neuropathic pain resulting from long-term nerve damage. It works by stabilizing hyperexcitable nerve cells and strengthening the body's natural pain-inhibiting pathways.

 

Q. Can I stop taking Jitogaba NT once my nerve pain stops?

A. No, neuropathic pain requires consistent, continuous management. Stopping abruptly can cause a severe relapse of pain, rebound anxiety, or withdrawal symptoms. Always consult your doctor to taper the dose safely.

 

Q. Why does Jitogaba NT 400/10 Tablet cause dry mouth?

A. Dry mouth is a common side effect of Jitogaba NT 400/10 Tablet due to the anticholinergic properties of Nortriptyline, which naturally reduce saliva production. To manage this symptom, sip water frequently, chew sugar-free gum, or practice good oral hygiene.

 

Q. Is Jitogaba NT 400/10 Tablet addictive?

A. No, Jitogaba NT 400/10 Tablet is not a habit-forming drug. However, its active component, Gabapentin, carries a potential for physical dependence. Because of this, you should never stop taking the medication abruptly, as doing so can trigger withdrawal symptoms like acute anxiety, insomnia, or increased pain. Always consult your doctor to taper off the dosage safely.

 

Q. Does Jitogaba NT 400/10 Tablet cause weight gain?

A. Yes, weight gain can be a side effect of this medication. Both Gabapentin (which can increase appetite and cause fluid retention) and Nortriptyline (which can alter metabolism) may contribute to weight changes. Eating a balanced diet and performing regular physical activity can help manage this.

 

Q. Can Jitogaba NT 400/10 Tablet affect my sexual health?

A. Yes, both active ingredients, particularly the antidepressant Nortriptyline, can occasionally cause sexual side effects. These may include a decreased sex drive (libido), erectile dysfunction, or difficulty achieving orgasm. Speak to your doctor if you experience these symptoms, as they can adjust your regimen.

 

 

 

References:

1. GABATOR NT. Gabapentin & Nortriptyline Hydrochloride Tablets. Torrentpharma. Last Revised: August 2022. Accessed On: 21st July 2026. Click Here

2. GABARING NT. Gabapentin & Nortriptyline. Centaurpharma. Last Revised: January 2022. Accessed On: 21st July 2026. Click Here

3. GABAPIN NT. Gabapentin & Nortriptyline Hydrochloride Tablets. PRESCRIBING INFORMATION. Intaspharma. Last Revised: 4th February 2026. Accessed On: 21st July 2026. Click Here